Relapsing Polychondritis (RPC) is a rare episodic and progressive multi-system inflammatory rheumatic disease involving all types of cartilage and connective tissue, which can be life-threatening, debilitating and can be difficult to diagnose. It was first described in 1923 and is characterized be recurrent, widespread and potentially severe and frightening episodes of inflammation of cartilaginous tissues. RPC affects cartilage in multiple systems, such as the ears, nose, larynx, trachea, bronchi and joints. In addition, it can affect proteoglycan rich tissues, such as the eyes, aorta, heart and skin. Central nervous system involvement has been noted in a minority of cases.
