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Almost all babies go through a fussy period. When crying lasts for longer than about three hours a day and is not caused by a medical problem (such as a hernia or infection), it is called colic. This phenomenon occurs in almost all babies. The only thing that differs is the degree.
About 20% of babies cry enough to meet the definition of colic. The timing varies, but colic usually affects babies beginning at about 3 weeks of age and peaking somewhere between 4-6 weeks of age. Colic will not last forever! After about 6 weeks of age, it usually begins improving, slowly but surely, and is generally gone by 12 weeks of age. When colic is still going strong at 12 weeks, it's important to consider another diagnosis (such as reflux).