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Cryoglobulinemia is part of a group of diseases that cause vasculitis - damage and inflammation of the blood vessels throughout the body. The disorder is grouped into three main types, depending on the type of antibody that is produced. Type I cryoglobulinemia is most often related to cancer of the blood or immune systems. Types II and III (also known as mixed cryoglobulinemia) are most often found in people who have a chronic (long-lasting) inflammatory condition, such as an autoimmune disease or hepatitis C. Most patients with mixed cryoglobulinemia have a chronic hepatitis C infection.