Peripheral vascular disease (PVD) happens when there is a narrowing of the blood vessels outside of your heart. A substance made up of fat and cholesterol, called plaque, builds up on the walls of the arteries that supply blood to the arms and legs. The plaque causes the arteries to narrow or become blocked. This can reduce or stop blood flow, usually to the legs, causing them to hurt or feel numb. If severe enough, blocked blood flow can cause tissue death. If this condition is left untreated, the foot or leg may need to be amputated.
